Study of the lorazepam: cyclodextrin inclusion complexes using electrospray ionization mass spectrometry

被引：26

作者：

Kobetic, R

Jursic, BS ^{[1
]}

Bonnette, S

Tsai, JSC

Salvatore, SJ

机构：

[1] Univ New Orleans, Dept Chem, New Orleans, LA 70148 USA

[2] Roche Diagnost Corp, R&D Dept, Indianapolis, IN 46250 USA

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 35期

关键词：

D O I：

10.1016/S0040-4039(01)01181-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

As an example of drug-cyclodextrin interactions in aqueous media, the cyclodextrin complexation of lorazepam was studied by electrospray ionization mass spectroscopy (ES-MS). It was concluded that highly concentrated aqueous hydroxypropylcyclodextrins are more suited for the drug complexation and that the inclusion complex includes one molecule of the drug with two and three cyclodextrin molecules as well as two molecules of the drug with three molecules of hydroxypropylcyclodextrins. It was postulated that in the hydroxycyclodextrin cavity the drug molecule decomposes via the elimination of one molecule of formaldehyde. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：6077 / 6082

页数：6

共 37 条

[21] IN-VITRO CORNEAL PERMEABILITY OF DICLOFENAC SODIUM IN FORMULATIONS CONTAINING CYCLODEXTRINS COMPARED TO THE COMMERCIAL PRODUCT VOLTAREN OPHTHA [J].

REER, O ;

BOOK, TK ;

MULLER, BW .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1994, 83 (09) :1345-1349

[22]

Salzman C., 1990, BENZODIAZEPINE DEPEN

[23] INCLUSION COMPLEXATION OF LORAZEPAM WITH BETA-CYCLODEXTRIN [J].

SANGHAVI, NM ;

CHOUDHARI, KB ;

MATHARU, RS ;

VISWANATHAN, L .

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 1993, 19 (06) :701-712

[24]

Sawada M, 1997, MASS SPECTROM REV, V16, P73

[25]

Selva A, 1996, J MASS SPECTROM, V31, P1364, DOI 10.1002/(SICI)1096-9888(199612)31:12<1364::AID-JMS432>3.0.CO

[26]

2-#

[27]

Selva A, 1998, J MASS SPECTROM, V33, P729, DOI 10.1002/(SICI)1096-9888(199808)33:8<729::AID-JMS687>3.0.CO

[28]

2-U

[29]

SHAPIRO YE, 1996, ZH STRUKT KHIM, V37, P876

[30]

Srinivasan K, 2000, RAPID COMMUN MASS SP, V14, P624, DOI 10.1002/(SICI)1097-0231(20000430)14:8<624::AID-RCM922>3.3.CO

← 1 2 3 4 →