Studies toward the total synthesis of scyphostatin: First entry to the highly functionalized cyclohexenone segment

被引：38

作者：

Izuhara, T ^{[1
]}

Katoh, T ^{[1
]}

机构：

[1] Sagami Chem Res Ctr, Sagamihara, Kanagawa 2290012, Japan

来源：

ORGANIC LETTERS | 2001年 / 3卷 / 11期

关键词：

D O I：

10.1021/ol015873s

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] The cyclohexenone segment 2 of scyphostatin (1), a potent inhibitor of neutral sphingomyelinase, was synthesized in an enantioselective manner starting from the bromo ether 5 and D-serinal derivative 3. The synthetic method features a coupling reaction of 5 with 3 to construct the asymmetric quaternary carbon center and a stereospecific epoxide ring formation as the key steps.

引用

页码：1653 / 1656

页数：4

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