Hydrodynamic properties of carbohydrate-coated dendrimers

被引:35
作者
Pavlov, GM
Korneeva, EV
Jumel, K
Harding, SE
Meijer, EW
Peerlings, HWI
Stoddart, JF
Nepogodiev, SA [1 ]
机构
[1] Univ Birmingham, Sch Chem, Birmingham B15 2TT, W Midlands, England
[2] St Petersburg Univ, Inst Phys, St Petersburg 19890, Russia
[3] Russian Acad Sci, Inst Macromol Cpds, St Petersburg 199004, Russia
[4] Univ Nottingham, Sch Biol, NCMH Unit, Loughborough LE12 5RD, Leics, England
[5] Eindhoven Univ Technol, Lab Macromol & Organ Chem, NL-5600 MB Eindhoven, Netherlands
[6] Univ Calif Los Angeles, Dept Chem & Biochem, Los Angeles, CA 90095 USA
[7] Univ Birmingham, Sch Chem, Birmingham B15 2TT, W Midlands, England
基金
英国生物技术与生命科学研究理事会; 英国工程与自然科学研究理事会;
关键词
carbohydrate; dendrimers; hydrodynamic properties; poly(propylene imine) dendrimers;
D O I
10.1016/S0144-8617(98)00091-5
中图分类号
O69 [应用化学];
学科分类号
081704 ;
摘要
The hydrodynamic properties of poly(propylene imine) dendrimers, modified with outer-surface beta-thiolactosyl residues ("lactodendrimers") of generation number 1-5, have been investigated by velocity sedimentation, translational diffusion, and viscosity measurements in 0.165% NaCl aqueous solution. It has been demonstrated that apparent molecular weights (from the Svedberg equation) M-sD of synthetic lactodendrimers, determined by sedimentation and diffusion experiments, are consistent with complete functionalization of initial poly(propylene imine) dendrimers with sugar residues. The values of M-sD range from 1900 to 45000 Da for generation numbers 1-5. Corresponding hydrodynamic (''equivalent Stokes'') radii range from similar to 10 to similar to 37 Angstrom. Scaling relations of the conformation-dependent sedimentation coefficient, translational diffusion coefficient and intrinsic viscosity with molecular weight have been considered in derail and are all indicative of a spherical molecule with an inhomogeneous distribution of density (Mark-Houwink-Kuhn-Sakurada a, b and epsilon, coefficients of similar to 0.24, similar to 0.69 and similar to 0.31, respectively). (C) 1999 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:195 / 202
页数:8
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