Recombinant human interleukin-6 induces hepatocyte growth factor production in cancer patients

被引:21
作者
de Jong, KP
van Gameren, MM
Bijzet, J
Limburg, PC
Sluiter, WJ
Slooff, MJH
de Vries, EGE
机构
[1] Univ Groningen, Univ Hosp, Dept Surg, Div Hepato Pancreato Biliary Surg & Liver Transpl, NL-9700 RB Groningen, Netherlands
[2] Univ Groningen, Univ Hosp, Dept Med Oncol, Groningen, Netherlands
[3] Univ Groningen, Univ Hosp, Dept Rheumatol, Groningen, Netherlands
[4] Univ Groningen, Univ Hosp, Dept Endocrinol, Groningen, Netherlands
[5] Univ Groningen, Fac Med, Groningen, Netherlands
关键词
acute phase proteins; hepatocyte growth factor; interleukin-6; liver regeneration;
D O I
10.1080/003655201750163132
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Background: Experiments in animals demonstrate an important role for interleukin-6 (IL-6) in liver regeneration. It is suggested that IL-6 initiates hepatocyte growth factor (HGF) synthesis. Methods: The aim of the study was to examine the effect of exogenously administered recombinant human IL-6 (rhlL-6), in doses of 0.5. 1.0, 2.5, 5, 10 and 20 mug/kg/day, on HGF serum levels in humans. Serum HGF levels were measured on days 1, 2, 3, 8 and 15 and were correlated with serum amyloid A (SAA) and C-reactive protein (CRP). Results: Median HGF levels increased to 124% at day 3 (P < 0.05) and 157% (P < 0.05) at day 8 as compared to 100% levels at day 1. An IL-6 dose-dependent increase in HGF was found at day 8 (R=0.53, P < 0.02). The percentual change in serum HGF level at day 8 correlated with IL-6 serum levels at day (R = 0.59, P < 0.01). HGF levels did not correlate with CRP and SAA. Conclusion: In humans, rhIL-6 administration resulted in an increase in serum HGF levels.
引用
收藏
页码:636 / 640
页数:5
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