15-Amido erythromycins:: Synthesis and in vitro activity of a new class of macrolide antibiotics

被引:16
作者
Shaw, SJ
Abbanat, D
Ashley, GW
Bush, K
Foleno, B
Macielag, M
Zhang, D
Myles, DC
机构
[1] Kosan Biosci Inc, Hayward, CA 94545 USA
[2] Johnson & Johnson Pharmaceut Res & Dev LLC, Raritan, NJ 08869 USA
关键词
chemobiosynthesis; erythromycin; antibacterial; diketide;
D O I
10.1038/ja.2005.19
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
An array of 15-amido substituted erythromycin A compounds was synthesized using a chemobiosynthesis approach. It was found that while the in vitro antibacterial activities of aryl amides were inferior to erythromycin A, substituted benzylamides showed equivalent and in some cases improved activity against the macrolide-resistant strains. The 15-amidoerythromycins represent a new class of antibacterial macrolides.
引用
收藏
页码:167 / 177
页数:11
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