Targeting SRC in glioblastoma tumors and brain metastases Rationale and preclinical studies

被引：115

作者：

Ahluwalia, Manmeet S.

de Groot, John ^{[2
]}

Liu, Wei ^{[1
]}

Gladson, Candece L. ^{[1
]}

机构：

[1] Cleveland Clin, Lerner Res Inst, Dept Canc Biol, Cleveland, OH 44195 USA

[2] Univ Texas MD Anderson Canc Ctr, Brain Tumor Ctr, Houston, TX 77030 USA

来源：

CANCER LETTERS | 2010年 / 298卷 / 02期

关键词：

SRC-family kinase; Targeted therapy; Glioma; Glioblastoma; Metastasis; FOCAL ADHESION KINASE; ENDOTHELIAL GROWTH-FACTOR; BREAST-CANCER INVASION; ADVANCED COLORECTAL CANCERS; PROMOTES CELL-SURVIVAL; CENTRAL-NERVOUS-SYSTEM; ACTIVATES C-SRC; TYROSINE KINASE; IN-VIVO; FAMILY KINASES;

D O I：

10.1016/j.canlet.2010.08.014

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Glioblastoma (GBM) is an extremely aggressive infiltrative tumor with a poor prognosis The regulatory approval of bevacizumab for recurrent GBM has confirmed that molecularly targeted agents have potential for GBM treatment Preclinical data showing that SRC and SRC-family kinase (SFKs) mediate intracellular signaling pathways controlling key biologic/oncogenic processes provide a strong rationale for investigating SRC/SFK inhibitors e g dasatinib in GBM and clinical studies are underway The activity of these agents against solid tumors suggests that they may also be useful in treating brain metastases This article reviews the potential for using SRC/SFK inhibitors to treat GBM and brain metastases (C) 2010 Elsevier Ireland Ltd All rights reserved

引用

收藏

页码：139 / 149

页数：11

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