Synthesis of new carbon-11 labeled cyclofenil derivatives for PET imaging of breast cancer estrogen receptors

被引：12

作者：

Gao, Mingzhang ^{[1
]}

Wang, Min ^{[1
]}

Mock, Bruce H. ^{[1
]}

Miller, Kathy D. ^{[2
]}

Sledge, George W. ^{[2
]}

Hutchins, Gary D. ^{[1
]}

Zheng, Qi-Huang ^{[1
]}

机构：

[1] Indiana Univ, Sch Med, Dept Radiol, Indianapolis, IN 46202 USA

[2] Indiana Univ, Sch Med, Dept Med, Indianapolis, IN 46202 USA

来源：

APPLIED RADIATION AND ISOTOPES | 2008年 / 66卷 / 04期

关键词：

cyclofenil derivatives; carbon-11; positron emission tomography (PET); breast cancer; estrogen receptors; imaging;

D O I：

10.1016/j.apradiso.2007.11.006

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Carbon-11 labeled cyclofenil derivatives, [C-11]methyl-2-{4-[bis(4-hydroxyphenyl)methylene]cyclohexyl}acetate ([C-11]16a), [C-11]methyl-4-[bis(4-hydroxyphenyl)methylene]cyclohex anecarboxylate ([C-11]16b), [C-11]methyl-2-{3-[bis(4-hydroxyphenyl)methylene]cyclohexyl}acetate ([C-11]18a), and [C-11]methyl-3-[bis(4-hydroxyphenyl)methylene]cyclohexanecarboxylate ([C-11]18b), have been synthesized as new potential PET agents for imaging breast cancer estrogen receptors. The target tracers were prepared by O-[C-11]methylation of their corresponding precursors using [C-11]CH3OTf and isolated by a simplified SPE purification procedure in 35-50% radiochemical yields decay corrected to EOB, 15-20 min overall synthesis time, and 74-111 GBq/mu mol specific activity at EOS. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：523 / 529

页数：7

共 15 条

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