Compatibility studies of aceclofenac with retard tablet excipients by means of thermal and FT-IR spectroscopic methods

被引：30

作者：

Aigner, Z. ^{[1
]}

Heinrich, R. ^{[2
]}

Sipos, E. ^{[2
]}

Farkas, G. ^{[1
]}

Ciurba, A. ^{[2
]}

Berkesi, O. ^{[3
]}

Szabo-Revesz, P. ^{[1
]}

机构：

[1] Univ Szeged, Dept Pharmaceut Technol, H-6720 Szeged, Hungary

[2] Univ Med & Pharm Targu Mures, Dept Pharmaceut Technol, Targu Mures 540139, Romania

[3] Univ Szeged, Dept Phys Chem & Mat Sci, H-6720 Szeged, Hungary

来源：

JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY | 2011年 / 104卷 / 01期

关键词：

Compatibility; Aceclofenac; Magnesium stearate; DSC; FT-IR; DIFFERENTIAL SCANNING CALORIMETRY; FORMULATIONS; DSC;

D O I：

10.1007/s10973-010-1105-1

中图分类号：

O414.1 [热力学];

学科分类号：

070201 [理论物理];

摘要：

The compatibility of aceclofenac with various tableting excipients was investigated by means of differential scanning calorimetry (DSC) and Fourier transform infrared spectroscopy (FT-IR). The excipients applied in the direct pressing retard tablets were Carbopol 940, hydroxypropyl-methyl-cellulose, microcrystalline cellulose, Aerosil 200 and magnesium stearate. The ingredients alone and their 1:1 (w/w) binary mixtures were investigated before and after accelerated storage. An interaction was observed only between aceclofenac and magnesium stearate. The DSC and FT-IR examinations indicated formation of the magnesium salt of aceclofenac. For the other mixtures, there was no incompatibility between the components.

引用

页码：265 / 271

页数：7

共 20 条

[1]

Thermal analysis of the antiretroviral zidovudine (AZT) and evaluation of the compatibility with excipients used in solid dosage forms [J].