Epigenetics in Alternative Pre-mRNA Splicing

被引：620

作者：

Luco, Reini F. ^{[1
]}

Allo, Mariano ^{[2
,3
]}

Schor, Ignacio E. ^{[2
,3
]}

Kornblihtt, Alberto R. ^{[2
,3
]}

Misteli, Tom ^{[1
]}

机构：

[1] NCI, NIH, Bethesda, MD 20892 USA

[2] Univ Buenos Aires, Fac Ciencias Exactas Nat, LFBM, Dept Fisiol Biol Mol, Buenos Aires, DF, Argentina

[3] Univ Buenos Aires, Fac Ciencias Exactas Nat, IFIBYNE CONICET, Buenos Aires, DF, Argentina

来源：

CELL | 2011年 / 144卷 / 01期

基金：

美国国家卫生研究院;

关键词：

CARBOXY-TERMINAL DOMAIN; SR PROTEIN FAMILY; POLYMERASE-II; DNA METHYLATION; INTRON REMOVAL; TRANSCRIPTION; RECRUITMENT; BINDING; POLYADENYLATION; YEAST;

D O I：

10.1016/j.cell.2010.11.056

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Alternative splicing plays critical roles in differentiation, development, and disease and is a major source for protein diversity in higher eukaryotes. Analysis of alternative splicing regulation has traditionally focused on RNA sequence elements and their associated splicing factors, but recent provocative studies point to a key function of chromatin structure and histone modifications in alternative splicing regulation. These insights suggest that epigenetic regulation determines not only what parts of the genome are expressed but also how they are spliced.

引用

收藏

页码：16 / 26

页数：11

相关论文

共 94 条

[1] PRECISION AND ORDERLINESS IN SPLICING [J].

AEBI, M ;

WEISSMANN, C .

TRENDS IN GENETICS, 1987, 3 (04) :102-107

[2] Control of alternative splicing through siRNA-mediated transcriptional gene silencing [J].

Allo, Mariano ;

Buggiano, Valeria ;

Fededa, Juan P. ;

Petrillo, Ezequiel ;

Schor, Ignacio ;

de la Mata, Manuel ;

Agirre, Eneritz ;

Plass, Mireya ;

Eyras, Eduardo ;

Abou Elela, Sherif ;

Klinck, Roscoe ;

Chabot, Benoit ;

Kornblihtt, Alberto R. .

NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2009, 16 (07) :717-U43

[3] Nucleosomes are well positioned in exons and carry characteristic histone modifications [J].

Andersson, Robin ;

Enroth, Stefan ;

Rada-Iglesias, Alvaro ;

Wadelius, Claes ;

Komorowski, Jan .

GENOME RESEARCH, 2009, 19 (10) :1732-1741

[4] Outcome of donor splice site mutations accounting for congenital afibrinogenemia reflects order of intron removal in the fibrinogen alpha gene (FGA) [J].

Attanasio, C ;

David, A ;

Neerman-Arbez, M .

BLOOD, 2003, 101 (05) :1851-1856

[5] Differential recruitment of nuclear receptor coactivators may determine alternative RNA splice site choice in target genes [J].

Auboeuf, D ;

Dowhan, DH ;

Kang, YK ;

Larkin, K ;

Lee, JW ;

Berget, SM ;

O'Malley, BW .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (08) :2270-2274

[6] CoAA, a nuclear receptor coactivator protein at the interface of transcriptional coactivation and RNA splicing [J].

Auboeuf, D ;

Dowhan, DH ;

Li, XT ;

Larkin, K ;

Ko, L ;

Berget, SM ;

O'Malley, BW .

MOLECULAR AND CELLULAR BIOLOGY, 2004, 24 (01) :442-453

[7] Coordinate regulation of transcription and splicing by steroid receptor coregulators [J].

Auboeuf, D ;

Hönig, A ;

Berget, SM ;

O'Malley, BW .

SCIENCE, 2002, 298 (5592) :416-419

[8] Deciphering the splicing code [J].

Barash, Yoseph ;

Calarco, John A. ;

Gao, Weijun ;

Pan, Qun ;

Wang, Xinchen ;

Shai, Ofer ;

Blencowe, Benjamin J. ;

Frey, Brendan J. .

NATURE, 2010, 465 (7294) :53-59

[9] The human SWI/SNF subunit Brm is a regulator of alternative splicing [J].

Batsché, E ;

Yaniv, M ;

Muchardt, C .

NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2006, 13 (01) :22-29

[10] SPLICING OF BALBIANI RING-1 GENE PREMESSENGER RNA OCCURS SIMULTANEOUSLY WITH TRANSCRIPTION [J].

BAUREN, G ;

WIESLANDER, L .

CELL, 1994, 76 (01) :183-192

← 1 2 3 4 5 6 7 8 9 10 →