Biological functions of interleukin-21 and its role in inflammation

被引：20

作者：

Pelletier, Martin

Girard, Denis ^{[1
]}

机构：

[1] INRS Inst Armand Fappier, Pointe Claire, PQ, Canada

[2] Univ Verona, Dept Pathol, Div Gen Pathol, I-37100 Verona, Italy

来源：

THESCIENTIFICWORLDJOURNAL | 2007年 / 7卷

关键词：

cytokine; interleukin-21 (IL-21); neutrophil; monocyte; macrophage; inflammation; CD132; cell signaling;

D O I：

10.1100/tsw.2007.275

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Interleukin-21 (IL-21), the most recently discovered CD132-dependent cytokine, is mainly produced by activated T lymphocytes, particularly the inflammatory Th-17 subset, and is believed to be a key factor in the transition between innate and acquired immunity. In the last few years, this cytokine has been shown to modulate the functions of T, B, and NK cells, as well as cells of myeloid origin. In addition, it was demonstrated that IL-21 is a potent antitumor agent, making it a promising candidate for the development of therapeutic tools. IL-21 has also been associated with different autoimmune and inflammatory diseases, such as rheumatoid arthritis and inflammatory bowel disease. This review will summarize the biological functions of IL-21 and its potential role in inflammation.

引用

收藏

页码：1715 / 1735

页数：21

相关论文

共 158 条

[1] High IL-21 receptor expression and apoptosis induction by IL-21 in follicular lymphoma [J].

Akamatsu, Norihiko ;

Yamada, Yasuaki ;

Hasegawa, Hiroo ;

Makabe, Koki ;

Asano, Ryutaro ;

Kumagai, Izumi ;

Murata, Ken ;

Maizum, Yoshitaka ;

Tsukasaki, Kunihiro ;

Tsuruda, Kazuto ;

Sugahara, Kazuyuki ;

AtogaMi, Sunao ;

Yanagihara, Katsunori ;

Kamihira, Shimeru .

CANCER LETTERS, 2007, 256 (02) :196-206

[2] IL-21 sustains CD28 expression on IL-15-activated human naive CD8+ T cells [J].

Alves, NL ;

Arosa, FA ;

van Lier, RAW .

JOURNAL OF IMMUNOLOGY, 2005, 175 (02) :755-762

[3]

ANDERSON DM, 1995, J BIOL CHEM, V270, P29862

[4] JunD/AP-1 and STAT3 are the major enhancer molecules for high Bcl6 expression in germinal center B cells [J].

Arguni, Eggi ;

Arima, Masafumi ;

Tsuruoka, Nobuhide ;

Sakamoto, Akemi ;

Hatano, Masahiko ;

Tokuhisa, Takeshi .

INTERNATIONAL IMMUNOLOGY, 2006, 18 (07) :1079-1089

[5] Molecular scanning of interleukin-21 gene and genetic susceptibility to type 1 diabetes [J].

Asano, Katsuaki ;

Ikegami, Hiroshi ;

Fujisawa, Tomomi ;

Nishino, Masanori ;

Nojima, Koji ;

Kawabata, Yumiko ;

Noso, Shinsuke ;

Hiromine, Yoshihisa ;

Fukai, Aya ;

Ogihara, Toshio .

HUMAN IMMUNOLOGY, 2007, 68 (05) :384-391

[6] Cutting edge:: The common γ-chain is an indispensable subunit of the IL-21 receptor complex [J].

Asao, H ;

Okuyama, C ;

Kumaki, S ;

Ishii, N ;

Tsuchiya, S ;

Foster, D ;

Sugamura, K .

JOURNAL OF IMMUNOLOGY, 2001, 167 (01) :1-5

[7] HEMATOPOIETIC RECEPTORS AND HELICAL CYTOKINES [J].

BAZAN, JF .

IMMUNOLOGY TODAY, 1990, 11 (10) :350-354

[8] Interleukin-2, interleukin-15, and their roles in human natural killer cells [J].

Becknell, B ;

Caligiuri, MA .

ADVANCES IN IMMUNOLOGY, VOL 86, 2005, 86 :209-239

[9] Program death-1 engagement upon TCR activation has distinct effects on costimulation and cytokine-driven proliferation: Attenuation of ICOS, IL-4, and IL-21, but not CD28, IL-7, and IL-15 responses [J].

Bennett, F ;

Luxenberg, D ;

Ling, V ;

Wang, IM ;

Marquette, K ;

Lowe, D ;

Khan, N ;

Veldman, G ;

Jacobs, KA ;

Valge-Archer, VE ;

Collins, M ;

Carreno, BM .

JOURNAL OF IMMUNOLOGY, 2003, 170 (02) :711-718

[10] Characterisation and expression analysis of interleukin 2 (IL-2) and IL-21 homologues in the Japanese pufferfish, Fugu rubripes, following their discovery by synteny [J].

Bird, S ;

Zou, J ;

Kono, T ;

Sakai, M ;

Dijkstra, JM ;

Secombes, C .

IMMUNOGENETICS, 2005, 56 (12) :909-923

← 1 2 3 4 5 6 7 8 9 10 →