Grafted thermo- and pH responsive co-polymers:: Surface-properties and bacterial adsorption

被引：21

作者：

Alarcón, CDL ^{[1
]}

Twaites, B ^{[1
]}

Cunliffe, D ^{[1
]}

Smith, JR ^{[1
]}

Alexander, C ^{[1
]}

机构：

[1] Univ Portsmouth, Sch Pharm & Biomed Sci, Portsmouth P01 2DT, Hants, England

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2005年 / 295卷 / 1-2期

基金：

英国工程与自然科学研究理事会;

关键词：

bacterial adsorption; thermoresponsive polymers; atomic force microscopy; Salmonella typhimurium; Bacillus cereus;

D O I：

10.1016/j.ijpharm.2005.01.037

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A series of responsive polymers displaying pH and temperature-mediated phase changes were prepared from N-isopropylacrylamide and omega-carboxylic acid functionalised acrylamides. These polymers were grafted to surfaces and their characteristics probed by atomic force microscopy in aqueous solutions. The effects of pH and temperature induced phase transitions on the short-term adsorption of the bacteria Salmonella typhimurium and Bacillus cereus from pure cultures were assessed. Contact angle studies indicated that pH and temperature-dependent surface properties were exhibited by the graft polymer surfaces. Temperature-dependent surface morphology changes Occurred through polymer graft phase transitions as observed ill AFM and accompanying changes in adhesion forces underwater were found to correlate with surface properties obtained from contact and measurements. Adsorption of S. typhimurium and B. cereus was not significantly altered as a function of pH, but attachment of both bacterial strains increased at temperatures above the polymer coil-globule transition indicating the importance of switching Surface hydrophobicity in controlling short-term bacterial adsorption. (c) 2005 Elsevier B.V. All rights reserved.

引用

页码：77 / 91

页数：15

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