Partition coefficients by curve fitting: The use of two different octanol volumes in a dual-phase potentiometric titration

被引：12

作者：

Clarke, FH ^{[1
]}

Cahoon, NM ^{[1
]}

机构：

[1] ROBERTSON MICROLIT LABS INC,MADISON,NJ 07940

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1996年 / 85卷 / 02期

关键词：

D O I：

10.1021/js950230p

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

It is shown that when two different volumes of the second phase are employed in a single dual-phase potentiometric titration, the partition coefficients of the most highly ionized species can be readily calculated by refinement of the parameters for the dual-phase titration equations. Graphical comparison of the calculated titration curve with that obtained experimentally is helpful in making initial estimates of the parameters.

引用

页码：178 / 183

页数：6

共 17 条

[1]

ALBERT A, 1984, DETERMINATION IONIZA, P50

[2]

AUSTEL V, 1983, QUANTITATIVE STRUCTU, P445

[3] PH-METRIC LOG-P .1. DIFFERENCE PLOTS FOR DETERMINING ION-PAIR OCTANOL-WATER PARTITION-COEFFICIENTS OF MULTIPROTIC SUBSTANCES [J].