CART peptides: Modulators of mesolimbic dopamine, feeding, and stress

被引：34

作者：

Dominguez, G

Vicentic, A

Del Giudice, EM

Jaworski, J

Hunter, RG

Kuhar, MJ

机构：

[1] Emory Univ, Yerkes Natl Primate Res Ctr, Div Neurosci, Atlanta, GA 30329 USA

[2] Univ Naples 2, Dept Pediat, I-80138 Naples, Italy

来源：

CURRENT STATUS OF DRUG DEPENDENCE / ABUSE STUDIES: CELLULAR AND MOLECULAR MECHANISMS OF DRUGS OF ABUSE AND NEUROTOXICITY | 2004年 / 1025卷

关键词：

feeding; stress; satiety; body weight; reward;

D O I：

10.1196/annals.1316.044

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

CART peptides have been shown to be peptide neurotransmitters and endocrine factors in a series of cumulative studies over the past eight years or so. This brief review touches on three aspects of CART: CART as a mediator or modulator of mesolimbic dopamine, CART's regulation by glucocorticoids, and CART as a regulator of feeding, satiety, and body weight. There have been several recent reviews and publications on various aspects of CART peptides. These aspects include the sequence and numbering of the peptides, and their structure, processing, and roles in various physiologic processes.

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收藏

页码：363 / 369

页数：7

相关论文

共 47 条

[1] Evidence of an orexigenic role for cocaine- and amphetamine-regulated transcript after administration into discrete hypothalamic nuclei [J].

Abbott, CR ;

Rossi, M ;

Wren, AM ;

Murphy, KG ;

Kennedy, AR ;

Stanley, SA ;

Zollner, AN ;

Morgan, DGA ;

Morgan, I ;

Ghatei, MA ;

Small, CJ ;

Bloom, SR .

ENDOCRINOLOGY, 2001, 142 (08) :3457-3463

[2] CART: from gene to function [J].

Adams, LD ;

Gong, W ;

Vechia, SD ;

Hunter, RG ;

Kuhar, MJ .

BRAIN RESEARCH, 1999, 848 (1-2) :137-140

[3] Intracerebroventricular CART peptide reduces rat ingestive behavior and alters licking microstructure [J].

Aja, S ;

Schwartz, GJ ;

Kuhar, MJ ;

Moran, TH .

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 2001, 280 (06) :R1613-R1619

[4] Cocaine-amphetamine-regulated transcript influences energy metabolism, anxiety and gastric emptying in mice [J].

Asakawa, A ;

Inui, A ;

Yuzuriha, H ;

Nagata, T ;

Kaga, T ;

Ueno, N ;

Fujino, MA ;

Kasuga, M .

HORMONE AND METABOLIC RESEARCH, 2001, 33 (09) :554-558

[5] Absence of cocaine- and amphetamine-regulated transcript results in obesity in mice fed a high caloric diet [J].

Asnicar, MA ;

Smith, DP ;

Yang, DD ;

Heiman, ML ;

Fox, N ;

Chen, YF ;

Hsiung, HM ;

Köster, A .

ENDOCRINOLOGY, 2001, 142 (10) :4394-4400

[6] Effects of adrenalectomy on CART expression in the rat arcuate nucleus [J].

Balkan, B ;

Koylu, E ;

Pogun, S ;

Kuhar, MJ .

SYNAPSE, 2003, 50 (01) :14-19

[7] CART gene promoter transcription is regulated by a cyclic adenosine monophosphate response element [J].

Barrett, P ;

Davidson, J ;

Morgan, P .

OBESITY RESEARCH, 2002, 10 (12) :1291-1298

[8] Addiction, dopamine, and the molecular mechanisms of memory [J].

Berke, JD ;

Hyman, SE .

NEURON, 2000, 25 (03) :515-532

[9] Genetic analysis of drug addiction: the role of cAMP response element binding protein [J].

Blendy, JA ;

Maldonado, R .

JOURNAL OF MOLECULAR MEDICINE-JMM, 1998, 76 (02) :104-110

[10]

BRENZ VMS, 2001, MOL CELL NEUROSCI, V17, P303

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