Cocaine-amphetamine-regulated transcript influences energy metabolism, anxiety and gastric emptying in mice

被引：62

作者：

Asakawa, A

Inui, A

Yuzuriha, H

Nagata, T

Kaga, T

Ueno, N

Fujino, MA

Kasuga, M

机构：

[1] Kobe Univ, Sch Med, Dept Internal Med 2, Chuo Ku, Kobe, Hyogo 6500017, Japan

[2] Yamanashi Med Univ, Dept Internal Med 1, Yamanashi, Japan

来源：

HORMONE AND METABOLIC RESEARCH | 2001年 / 33卷 / 09期

关键词：

anxiogenic; cocaine-amphetamine-regulated transcript feeding; gastric emptying; intracerebroventricular; mice; oxygen consumption;

D O I：

10.1055/s-2001-17205

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

This study was designed to investigate the effects of cocaine-amphetamine-regulated transcript (CART), a recently discovered hypothalamic neuropeptide, on food intake, anxiety, oxygen consumption and gastric emptying in mice. Intracerebroventricular (i.c.v.) injection of CART (1 - 100 pmol) markedly reduced food intake in a dose-related manner. A significant decrease was observed 20 min after i. c. v. injection of CART and continued for four hours. In the elevated plus maze test, i.c.v. CART injection significantly raised the normal preference for the closed arms. Furthermore, the i. c. v. injection of CART significantly reduced oxygen consumption and gastric emptying rate. These results suggest that CART modulates feeding, emotion, and autonomic functions in mice.

引用

页码：554 / 558

页数：5

共 28 条

[1]

Urocrotin reduces food intake and gastric emptying in lean and ob/ob obese mice [J].