P(i-BuNCH2CH2)3N:: An efficient ligand for the direct α-arylation of nitriles with aryl bromides

被引：104

作者：

You, JS ^{[1
]}

Verkade, JG ^{[1
]}

机构：

[1] Iowa State Univ Sci & Technol, Dept Chem, Ames, IA 50011 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2003年 / 68卷 / 21期

关键词：

D O I：

10.1021/jo034779h

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new catalyst system for the synthesis of alpha-aryl-substituted nitriles is reported. The bicyclic triaminophosphine P(i-BuNCH2CH2)(3)N (1b) serves as an efficient and versatile ligand for the palladium-catalyzed direct alpha-arylation of nitriles with aryl bromides. Using ligand 1b, ethyl cyanoacetate and primary as well as secondary nitriles are efficiently coupled with a wide variety of aryl bromides possessing electron-rich, electron-poor, electron-neutral, and sterically hindered groups.

引用

页码：8003 / 8007

页数：5

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