SYNTHESIS AND PROPERTIES OF ENANTIOPURE BICYCLIC AMIDINES

被引：30

作者：

CONVERY, MA

DAVIS, AP

DUNNE, CJ

MACKINNON, JW

机构：

[1] UNIV OXFORD TRINITY COLL,DEPT CHEM,DUBLIN 2,IRELAND

[2] GLAXO GRP RES LTD,WARE SG12 0DP,HERTS,ENGLAND

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 24期

关键词：

D O I：

10.1016/0040-4039(95)00739-Y

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The enantiopure bicyclic amidine bases 5a-c were synthesized from alcohol 8, via alkylation of the appropriate nitriles. The phenylsulphonylamidine 5a was subjected to X-ray crystallography as its nitrate salt, and was shown by H-1 NMR to differentiate analytically between the enantiomers of chiral carboxylic acids.

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页码：4279 / 4282

页数：4

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