Formation of novel secondary metabolites by bacterial multimodular assembly lines:: deviations from textbook biosynthetic logic

被引：102

作者：

Wenzel, SC ^{[1
]}

Müller, R ^{[1
]}

机构：

[1] Univ Saarland, D-66041 Saarbrucken, Germany

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 2005年 / 9卷 / 05期

关键词：

D O I：

10.1016/j.cbpa.2005.08.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Microorganisms produce an immense variety of natural products with useful biological activities. These compounds are often biosynthesized by multifunctional megasynthetases known as polyketide synthases and nonribosomal peptide synthetases. Recent literature on these natural product assembly lines suggests that they have a much greater mechanistic diversity than originally anticipated.

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页码：447 / 458

页数：12

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