A reexamination of Biginelli-like multicomponent condensation reaction: One-pot regioselective synthesis of spiro heterobicyclic rings

被引：43

作者：

Shaabani, Ahmad ^{[1
]}

Bazgir, Ayoob ^{[1
]}

Bijanzadeh, Hamid Reza ^{[2
]}

机构：

[1] Shahid Beheshti Univ, Dept Chem, Tehran 1983963113, Iran

[2] Tarbiat Modares Univ, Dept Chem, Tehran, Iran

来源：

MOLECULAR DIVERSITY | 2004年 / 8卷 / 02期

关键词：

barbituric acid; Biginelli reaction; Meldrum's acid; multicomponent; solvent-free; spiro heterobicyclic rings;

D O I：

10.1023/B:MODI.0000025613.35304.25

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A pseudo four-component reaction is described, leading to the efficient regioselective synthesis of sigma symmetric spiro heterobicyclic rings using aldehydes and urea in the presence of cyclic beta-diester or beta-diamides such as Meldrum's acid or barbituric acid derivatives. The reaction needs no added catalyst and proceeds solvent-free conditions at 80 degrees C.

引用

页码：141 / 145

页数：5

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