Flippin' lipids

被引:40
作者
Clark, Marcus R. [1 ,2 ]
机构
[1] Univ Chicago, Dept Med, Rheumatol Sect, Chicago, IL 60637 USA
[2] Univ Chicago, Gwen Knapp Ctr Lupus Res, Chicago, IL 60637 USA
关键词
PHOSPHATIDYLSERINE; RECOMBINATION; ATP11C;
D O I
10.1038/ni.2024
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
B cell generation is disturbed in four newly identified mouse mutants bearing X-linked mutations in the gene encoding the ATPase ATP11C. These findings suggest that the distribution of membrane phospholipids confers a yet-to-be delineated developmental signal.
引用
收藏
页码:373 / 375
页数:3
相关论文
共 12 条
[1]   Regulation of interleukin 7-dependent immunoglobulin heavy-chain variable gene rearrangements by transcription factor STAT5 [J].
Bertolino, E ;
Reddy, K ;
Medina, KL ;
Parganas, E ;
Ihle, J ;
Singh, H .
NATURE IMMUNOLOGY, 2005, 6 (08) :836-843
[2]   Phospholipid flippases [J].
Daleke, David L. .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (02) :821-825
[3]   Transcriptional regulation of lymphocyte development [J].
Dias, Sheila ;
Xu, Wei ;
McGregor, Stephanie ;
Kee, Barbara .
CURRENT OPINION IN GENETICS & DEVELOPMENT, 2008, 18 (05) :441-448
[4]   The Distribution and Function of Phosphatidylserine in Cellular Membranes [J].
Leventis, Peter A. ;
Grinstein, Sergio .
ANNUAL REVIEW OF BIOPHYSICS, VOL 39, 2010, 39 :407-427
[5]   Role of STAT5 in controlling cell survival and immunoglobulin gene recombination during pro-B cell development [J].
Malin, Stephen ;
McManus, Shane ;
Cobaleda, Cesar ;
Novatchkova, Maria ;
Delogu, Alessio ;
Bouillet, Philippe ;
Strasser, Andreas ;
Busslinger, Meinrad .
NATURE IMMUNOLOGY, 2010, 11 (02) :171-U97
[6]   Ras orchestrates exit from the cell cycle and light-chain recombination during early B cell development [J].
Mandal, Malay ;
Powers, Sarah E. ;
Ochiai, Kyoko ;
Georgopoulos, Katia ;
Kee, Barbara L. ;
Singh, Harinder ;
Clark, Marcus R. .
NATURE IMMUNOLOGY, 2009, 10 (10) :1110-U91
[7]   Linking phospholipid flippases to vesicle-mediated protein transport [J].
Muthusamy, Baby-Periyanayaki ;
Natarajan, Paramasivam ;
Zhou, Xiaoming ;
Graham, Todd R. .
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 2009, 1791 (07) :612-619
[8]   The P4-type ATPase ATP11C is essential for B lymphopoiesis in adult bone marrow [J].
Siggs, Owen M. ;
Arnold, Carrie N. ;
Huber, Christoph ;
Pirie, Elaine ;
Xia, Yu ;
Lin, Pei ;
Nemazee, David ;
Beutler, Bruce .
NATURE IMMUNOLOGY, 2011, 12 (05) :434-U89
[9]  
Singh H, 2007, ADV EXP MED BIOL, V596, P57
[10]   A gene encoding a liver-specific ABC transporter is mutated in progressive familial intrahepatic cholestasis [J].
Strautnieks, SS ;
Bull, LN ;
Knisely, AS ;
Kocoshis, S ;
Dahl, N ;
Arnell, H ;
Sokal, E ;
Dahan, K ;
Childs, S ;
Ling, V ;
Tanner, MS ;
Kagalwalla, AF ;
Németh, A ;
Pawlowska, J ;
Baker, A ;
Mieli-Vergani, G ;
Freimer, NB ;
Gardiner, RM ;
Thompson, RJ .
NATURE GENETICS, 1998, 20 (03) :233-238