Orphan SeID proteins and selenium-dependent molybdenum hydroxylases

被引:33
作者
Haft, Daniel H. [1 ]
Self, William T. [2 ]
机构
[1] J Craig Venter Inst, Dept Bioinformat, Rockville, MD 20850 USA
[2] Univ Cent Florida, Coll Med, Burnett Sch Biomed Sci, Dept Mol Biol & Microbiol, Orlando, FL 32826 USA
基金
美国国家科学基金会;
关键词
D O I
10.1186/1745-6150-3-4
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Bacterial and Archaeal cells use selenium structurally in selenouridine-modified tRNAs, in proteins translated with selenocysteine, and in the selenium-dependent molybdenum hydroxylases (SDMH). The first two uses both require the selenophosphate synthetase gene, selD. Examining over 500 complete prokaryotic genomes finds selD in exactly two species lacking both the selenocysteine and selenouridine systems, Enterococcus faecalis and Haloarcula marismortui. Surrounding these orphan selD genes, forming bidirectional best hits between species, and detectable by Partial Phylogenetic Profiling vs. selD, are several candidate molybdenum hydroxylase subunits and accessory proteins. We propose that certain accessory proteins, and orphan selD itself, are markers through which new selenium-dependent molybdenum hydroxylases can be found.
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