Epigenetic Mechanisms that Regulate Cell Identity

被引：91

作者：

Barrero, Maria J. ^{[1
]}

Boue, Stephanie ^{[1
]}

Izpisua Belmonte, Juan Carlos ^{[1
,2
]}

机构：

[1] Ctr Regenerat Med Barcelona, Barcelona 08003, Spain

[2] Salk Inst Biol Studies, La Jolla, CA 92037 USA

来源：

CELL STEM CELL | 2010年 / 7卷 / 05期

关键词：

EMBRYONIC STEM-CELLS; DEVELOPMENTAL REGULATORS; CHROMATIN SIGNATURES; INTERACTION NETWORK; GENE-REGULATION; PLURIPOTENT; METHYLATION; POLYCOMB; COMPLEX; CANCER;

D O I：

10.1016/j.stem.2010.10.009

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Individual cell fate decisions can vary according to changes in gene expression in response to environmental, developmental, or metabolic cues. This plasticity is tightly regulated during embryonic development and mediated by the exquisitely coordinated activation and repression of groups of genes. Genes that become repressed are immersed in a condensed chromatin environment that renders them refractory to stimulation. This mechanism is responsible for both the loss of cell plasticity during differentiation and the preservation of cell identity. Understanding the molecular events involved in the establishment and maintenance of these restrictive domains will benefit the design of strategies for cellular reprogramming, differentiation, and cancer treatment.

引用

页码：565 / 570

页数：6

共 51 条

[41] Bivalent domains enforce transcriptional memory of DNA methylated genes in cancer cells [J].

Rodriguez, Jairo ;

Munoz, Mar ;

Vives, Laura ;

Frangou, Costas G. ;

Groudine, Mark ;

Peinado, Miguel A. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (50) :19809-19814

[42] Aberrant Epigenetic Silencing of Tumor Suppressor Genes Is Reversed by Direct Reprogramming [J].

Ron-Bigger, Shulamit ;

Bar-Nur, Ori ;

Isaac, Sara ;

Bocker, Michael ;

Lyko, Frank ;

Eden, Amir .

STEM CELLS, 2010, 28 (08) :1349-1354

[43] Chromatin-Remodeling Components of the BAF Complex Facilitate Reprogramming [J].

Singhal, Nishant ;

Graumann, Johannes ;

Wu, Guangming ;

Arauzo-Bravo, Marcos J. ;

Han, Dong Wook ;

Greber, Boris ;

Gentile, Luca ;

Mann, Matthias ;

Schoeler, Hans R. .

CELL, 2010, 141 (06) :943-955

[44] Role of the Murine Reprogramming Factors in the Induction of Pluripotency [J].

Sridharan, Rupa ;

Tchieu, Jason ;

Mason, Mike J. ;

Yachechko, Robin ;

Kuoy, Edward ;

Horvath, Steve ;

Zhou, Qing ;

Plath, Kathrin .

CELL, 2009, 136 (02) :364-377

[45] Aberrant silencing of imprinted genes on chromosome 12qF1 in mouse induced pluripotent stem cells [J].

Stadtfeld, Matthias ;

Apostolou, Effie ;

Akutsu, Hidenori ;

Fukuda, Atsushi ;

Follett, Patricia ;

Natesan, Sridaran ;

Kono, Tomohiro ;

Shioda, Toshi ;

Hochedlinger, Konrad .

NATURE, 2010, 465 (7295) :175-U55

[46] Polycomb Group Proteins Set the Stage for Early Lineage Commitment [J].

Surface, Lauren E. ;

Thornton, Seraphim R. ;

Boyer, Laurie A. .

CELL STEM CELL, 2010, 7 (03) :288-298

[47] Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors [J].

Takahashi, Kazutoshi ;

Yamanaka, Shinya .

CELL, 2006, 126 (04) :663-676

[48] Chromatin signature of embryonic pluripotency is established during genome activation [J].

Vastenhouw, Nadine L. ;

Zhang, Yong ;

Woods, Ian G. ;

Imam, Farhad ;

Regev, Aviv ;

Liu, X. Shirley ;

Rinn, John ;

Schier, Alexander F. .

NATURE, 2010, 464 (7290) :922-U143

[49] A protein interaction network for pluripotency of embryonic stem cells [J].

Wang, Jianlong ;

Rao, Sridhar ;

Chu, Jianlin ;

Shen, Xiaohua ;

Levasseur, Dana N. ;

Theunissen, Thorold W. ;

Orkin, Stuart H. .

NATURE, 2006, 444 (7117) :364-368

[50] Epigenetic stem cell signature in cancer [J].

Widschwendter, Martin ;

Fiegl, Heidi ;

Egle, Daniel ;

Mueller-Holzner, Elisabeth ;

Spizzo, Gilbert ;

Marth, Christian ;

Weisenberger, Daniel J. ;

Campan, Mihaela ;

Young, Joanne ;

Jacobs, Ian ;

Laird, Peter W. .

NATURE GENETICS, 2007, 39 (02) :157-158

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