Sequential intermolecular aminopalladation/ortho-arene C-H activation reactions of N-phenylpropiolamides with phthalimide

被引：90

作者：

Tang, Shi ^{[1
,2
]}

Peng, Peng ^{[2
]}

Pi, Shao-Feng ^{[2
]}

Liang, Yun ^{[2
]}

Wang, Nai-Xing ^{[1
]}

Li, Jin-Heng ^{[2
]}

机构：

[1] Chinese Acad Sci, Tech Inst Phys & Chem, Beijing 100080, Peoples R China

[2] Hunan Normal Univ, Key Lab Chem Biol & Tradit Chinese Med Res, Changsha 410081, Peoples R China

来源：

ORGANIC LETTERS | 2008年 / 10卷 / 06期

关键词：

D O I：

10.1021/ol800080w

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel palladium-catalyzed intermolecular aminopalladation/C-H activation method for selectively synthesizing (E)-(2-oxindolin-3-ylidene)phthalimides has been developed. In the presence of Pd(OAc)(2) and Phl(OAc)(2), alkynes were difunctionalized with a phthalimide and an arene Sp(2) C-H bond to selectively synthesize (E)-(2-oxoindolin-3-ylidene)phthalimides, which products are of great potential pharmaceutical value products in many major therapeutic areas, such as oncology, inflammation, neurology, immunology, and endocrinology. To the best of our knowledge, the reaction serves as the first example of intermolecular aminopalladation/C-H activation reactions of alkynes.

引用

页码：1179 / 1182

页数：4

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