Purpurins and benzochlorins as sensitizers for photodynamic therapy

被引：30

作者：

Garbo, GM ^{[1
]}

机构：

[1] UNIV TOLEDO,DEPT CHEM,TOLEDO,OH 43606

来源：

JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY | 1996年 / 34卷 / 2-3期

关键词：

photodynamic therapy; purpurins; benzochlorin; photosensitizers; fluorescence;

D O I：

10.1016/1011-1344(96)07343-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Purpurins and benzochlorins are hydrophobic second generation photosensitizers, which have sizable absorption in the 650-780 nm range and exhibit photodynamic activity against tumors after visible light treatment. This review summarizes the published data regarding these compounds: from the spectroscopic, photophysical and photochemical characteristics to the in vivo and in vitro photodynamic inactivation of tumors and normal tissue effects. Some mechanistic studies using both the Sn-etiopurpurin and/or the Cu-benzochlorin derivatives are also reviewed.

引用

页码：109 / 116

页数：8

共 63 条

[1]

ARNOLD DP, 1978, J CHEM SOC P1, P1600

[2] ROLE OF HIGH-DENSITY, LOW-DENSITY AND VERY LOW-DENSITY LIPOPROTEINS IN THE TRANSPORT AND TUMOR-DELIVERY OF HEMATOPORPHYRIN INVIVO [J].