Purpurins and benzochlorins as sensitizers for photodynamic therapy

被引:30
作者
Garbo, GM [1 ]
机构
[1] UNIV TOLEDO,DEPT CHEM,TOLEDO,OH 43606
关键词
photodynamic therapy; purpurins; benzochlorin; photosensitizers; fluorescence;
D O I
10.1016/1011-1344(96)07343-5
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Purpurins and benzochlorins are hydrophobic second generation photosensitizers, which have sizable absorption in the 650-780 nm range and exhibit photodynamic activity against tumors after visible light treatment. This review summarizes the published data regarding these compounds: from the spectroscopic, photophysical and photochemical characteristics to the in vivo and in vitro photodynamic inactivation of tumors and normal tissue effects. Some mechanistic studies using both the Sn-etiopurpurin and/or the Cu-benzochlorin derivatives are also reviewed.
引用
收藏
页码:109 / 116
页数:8
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