Purpurins and benzochlorins as sensitizers for photodynamic therapy

被引：30

作者：

Garbo, GM ^{[1
]}

机构：

[1] UNIV TOLEDO,DEPT CHEM,TOLEDO,OH 43606

来源：

JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY | 1996年 / 34卷 / 2-3期

关键词：

photodynamic therapy; purpurins; benzochlorin; photosensitizers; fluorescence;

D O I：

10.1016/1011-1344(96)07343-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Purpurins and benzochlorins are hydrophobic second generation photosensitizers, which have sizable absorption in the 650-780 nm range and exhibit photodynamic activity against tumors after visible light treatment. This review summarizes the published data regarding these compounds: from the spectroscopic, photophysical and photochemical characteristics to the in vivo and in vitro photodynamic inactivation of tumors and normal tissue effects. Some mechanistic studies using both the Sn-etiopurpurin and/or the Cu-benzochlorin derivatives are also reviewed.

引用

收藏

页码：109 / 116

页数：8

相关论文

共 63 条

[51] SPECTROSCOPIC STUDIES OF TIN ETHYL ETIOPURPURIN IN HOMOGENEOUS AND HETEROGENEOUS SYSTEMS [J].

SEKHER, P ;

GARBO, GM .

JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY, 1993, 20 (2-3) :117-125

[52] HEMODYNAMIC-EFFECT OF THE METALLOPURPURIN SNET2 AND LIGHT ON TRANSPLANTABLE FANFT INDUCED BLADDER-TUMOR [J].

SELMAN, SH ;

QIN, BS ;

JAMES, HR ;

KECK, RW ;

GARBO, GM ;

MORGAN, AR .

JOURNAL OF UROLOGY, 1990, 143 (03) :630-633

[53] A DOSE-RESPONSE ANALYSIS OF PURPURIN DERIVATIVES USED AS PHOTOSENSITIZERS FOR THE PHOTODYNAMIC TREATMENT OF TRANSPLANTABLE FANFT INDUCED UROTHELIAL TUMORS [J].

SELMAN, SH ;

GARBO, GM ;

KECK, RW ;

KREIMERBIRNBAUM, M ;

MORGAN, AR .

JOURNAL OF UROLOGY, 1987, 137 (06) :1255-1257

[54] COPPER BENZOCHLORIN, A NOVEL PHOTOSENSITIZER FOR PHOTODYNAMIC THERAPY - EFFECTS ON A TRANSPLANTABLE UROTHELIAL TUMOR [J].

SELMAN, SH ;

HAMPTON, JA ;

MORGAN, AR ;

KECK, RW ;

BALKANY, AD ;

SKALKOS, D .

PHOTOCHEMISTRY AND PHOTOBIOLOGY, 1993, 57 (04) :681-685

[55] IMINIUM SALT BENZOCHLORINS - STRUCTURE-ACTIVITY RELATIONSHIP STUDIES [J].

SKALKOS, D ;

HAMPTON, JA ;

KECK, RW ;

WAGONER, M ;

SELMAN, SH .

PHOTOCHEMISTRY AND PHOTOBIOLOGY, 1994, 59 (02) :175-181

[56]

SKALKOS D, 1992, MED CHEM RES, V2, P276

[57]

SNYDER AB, 1996, 6 M INT PHOT ASS MEL

[58] EFFECT OF THE DELIVERY SYSTEM ON THE BIODISTRIBUTION OF GE(IV) OCTABUTOXY-PHTHALOCYANINES IN TUMOR-BEARING MICE [J].

SONCIN, M ;

POLO, L ;

REDDI, E ;

JORI, G ;

KENNEY, ME ;

CHENG, G ;

RODGERS, MAJ .

CANCER LETTERS, 1995, 89 (01) :101-106

[59]

THIEL G, 1986, CLIN NEPHROL, V25, pS40

[60] UPTAKE OF LOW-DENSITY LIPOPROTEINS BY HUMAN LEUKEMIC-CELLS INVIVO - RELATION TO PLASMA-LIPOPROTEIN LEVELS AND POSSIBLE RELEVANCE FOR SELECTIVE CHEMOTHERAPY [J].

VITOLS, S ;

ANGELIN, B ;

ERICSSON, S ;

GAHRTON, G ;

JULIUSSON, G ;

MASQUELIER, M ;

PAUL, C ;

PETERSON, C ;

RUDLING, M ;

SODERBERGREID, K ;

TIDEFELT, U .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (07) :2598-2602

← 1 2 3 4 5 6 7 →