Mitogen-activated protein (MAP) kinase pathways: Regulation and physiological functions

被引：3564

作者：

Pearson, G ^{[1
]}

Robinson, F ^{[1
]}

Gibson, TB ^{[1
]}

Xu, BE ^{[1
]}

Karandikar, M ^{[1
]}

Berman, K ^{[1
]}

Cobb, MH ^{[1
]}

机构：

[1] Univ Texas, SW Med Ctr, Dept Pharmacol, Dallas, TX 75390 USA

来源：

ENDOCRINE REVIEWS | 2001年 / 22卷 / 02期

关键词：

D O I：

10.1210/er.22.2.153

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Mitogen-activated protein (MAP) kinases comprise a family of ubiquitous proline-directed, protein-serine/threonine kinases, which participate in signal transduction pathways that control intracellular events including acute responses to hormones and major developmental changes in organisms. MAP kinases Lie in protein kinase cascades. This review discusses the regulation and functions of mammalian MAP kinases. Nonenzymatic mechanisms that impact MAP kinase functions and findings from gene disruption studies are highlighted. Particular emphasis is on ERK1/2.

引用

页码：153 / 183

页数：31

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