Mitogen-activated protein (MAP) kinase pathways: Regulation and physiological functions

被引：3564

作者：

Pearson, G ^{[1
]}

Robinson, F ^{[1
]}

Gibson, TB ^{[1
]}

Xu, BE ^{[1
]}

Karandikar, M ^{[1
]}

Berman, K ^{[1
]}

Cobb, MH ^{[1
]}

机构：

[1] Univ Texas, SW Med Ctr, Dept Pharmacol, Dallas, TX 75390 USA

来源：

ENDOCRINE REVIEWS | 2001年 / 22卷 / 02期

关键词：

D O I：

10.1210/er.22.2.153

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Mitogen-activated protein (MAP) kinases comprise a family of ubiquitous proline-directed, protein-serine/threonine kinases, which participate in signal transduction pathways that control intracellular events including acute responses to hormones and major developmental changes in organisms. MAP kinases Lie in protein kinase cascades. This review discusses the regulation and functions of mammalian MAP kinases. Nonenzymatic mechanisms that impact MAP kinase functions and findings from gene disruption studies are highlighted. Particular emphasis is on ERK1/2.

引用

页码：153 / 183

页数：31

共 449 条

[61] HOW MAP KINASES ARE REGULATED [J].

COBB, MH ;

GOLDSMITH, EJ .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (25) :14843-14846

[62] MAP kinase pathways [J].

Cobb, MH .

PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY, 1999, 71 (3-4) :479-500

[63] Dimerization in MAP-kinase signaling [J].

Cobb, MH ;

Goldsmith, EJ .

TRENDS IN BIOCHEMICAL SCIENCES, 2000, 25 (01) :7-9

[64] G alpha(12) stimulates c-Jun NH2-terminal kinase through the small G proteins Ras and Rac [J].

Collins, LR ;

Minden, A ;

Karin, M ;

Brown, JH .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (29) :17349-17353

[65]

Corbit KC, 1999, MOL CELL BIOL, V19, P4209

[66] THE SMALL GTP-BINDING PROTEINS RAC1 AND CDC42 REGULATE THE ACTIVITY OF THE JNK/SAPK SIGNALING PATHWAY [J].

COSO, OA ;

CHIARIELLO, M ;

YU, JC ;

TERAMOTO, H ;

CRESPO, P ;

XU, NG ;

MIKI, T ;

GUTKIND, JS .

CELL, 1995, 81 (07) :1137-1146

[67] TRANSFORMING G-PROTEIN-COUPLED RECEPTORS POTENTLY ACTIVATE JNK (SAPK) - EVIDENCE FOR A DIVERGENCE FROM THE TYROSINE KINASE SIGNALING PATHWAY [J].

COSO, OA ;

CHIARIELLO, R ;

KALINEC, G ;

KYRIAKIS, JM ;

WOODGETT, J ;

GUTKIND, JS .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (10) :5620-5624

[68] A PUTATIVE PROTEIN-KINASE OVERCOMES PHEROMONE-INDUCED ARREST OF CELL CYCLING IN S-CEREVISIAE [J].

COURCHESNE, WE ;

KUNISAWA, R ;

THORNER, J .

CELL, 1989, 58 (06) :1107-1119

[69] ACTIVATION OF MAP KINASE KINASE IS NECESSARY AND SUFFICIENT FOR PC12 DIFFERENTIATION AND FOR TRANSFORMATION OF NIH 3T3 CELLS [J].

COWLEY, S ;

PATERSON, H ;

KEMP, P ;

MARSHALL, CJ .

CELL, 1994, 77 (06) :841-852

[70] THE PRIMARY STRUCTURE OF MEK, A PROTEIN-KINASE THAT PHOSPHORYLATES THE ERK GENE-PRODUCT [J].

CREWS, CM ;

ALESSANDRINI, A ;

ERIKSON, RL .

SCIENCE, 1992, 258 (5081) :478-480

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