Organocatalytic asymmetric Michael addition of 2,4-pentandione to nitroolefins

被引：247

作者：

Wang, J ^{[1
]}

Li, H

Duan, WH

Zu, LS

Wang, W

机构：

[1] Univ New Mexico, Dept Chem, Albuquerque, NM 87131 USA

[2] Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China

来源：

ORGANIC LETTERS | 2005年 / 7卷 / 21期

关键词：

D O I：

10.1021/ol0519137

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel binaphthyl-derived amine thiourea organocatalyst has been developed and demonstrated to efficiently catalyze Michael addition reactions (using as low as 1 mol % loading) of diketones to nitroalkenes with remarkably high enantioselectivities.

引用

页码：4713 / 4716

页数：4

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