Intramolecular acylations of gamma-benzoyloxy phosphine oxides: Synthesis of optically active cyclopropyl ketones

被引：30

作者：

Nelson, A ^{[1
]}

Warren, S ^{[1
]}

机构：

[1] UNIV CAMBRIDGE,CHEM LAB,CAMBRIDGE CB2 1EW,ENGLAND

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 09期

关键词：

D O I：

10.1016/0040-4039(96)00049-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Intramolecular acylation of gamma-benzoyloxy phosphine oxides with LDA in the presence of Me(3)SiCl gives silyl ethers with high stereoselectivity: treatment of these silyl ethers with t-BuOK gives optically active di- and trisubstituted cyclopropyl ketones in good yield.

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页码：1501 / 1504

页数：4

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