A novel MPTP primate model of Parkinson's disease: Neurochemical and clinical changes

被引：32

作者：

Eberling, JL

Jagust, WJ

Taylor, S

Bringas, J

Pivirotto, P

VanBrocklin, HF

Bankiewicz, KS

机构：

[1] Univ Calif Berkeley, Lawrence Berkeley Lab, Ctr Funct Imaging, Berkeley, CA 94720 USA

[2] Martinez VA Med Ctr, Dept Neurol, Davis, CA USA

[3] Univ Calif Davis, Davis, CA USA

[4] CroMedica, Orinda, CA USA

来源：

BRAIN RESEARCH | 1998年 / 805卷 / 1-2期

关键词：

Parkinson's disease; MPTP; monkey; PET; dopamine; FMT;

D O I：

10.1016/S0006-8993(98)00710-0

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Positron emission tomography (PET) and the dopamine (DA) metabolism tracer, [F-18]6-fluoro-L-m-tyrosine (FMT) were used to evaluate the relationship between DA metabolism and the clinical stage of parkinsonism monkeys following either unilateral ICA MPTP infusion or unilateral ICA MPTP infusion and subsequent varying sequential systemic doses of MPTP. Clinical stage corresponded to PET measures of striatal DA metabolism, showing the usefulness of the overlesioned hemiparkinsonian monkey as a stable model of various stages of Parkinson's disease (PD). (C) 1998 Elsevier Science B.V. All rights reserved.

引用

页码：259 / 262

页数：4

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[3]

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