Conjugates of stimuli-responsive polymers and proteins

被引：260

作者：

Hoffman, Allan S. ^{[1
]}

Stayton, Patrick S. ^{[1
]}

机构：

[1] Univ Washington, Dept Bioengn, Seattle, WA 98195 USA

来源：

PROGRESS IN POLYMER SCIENCE | 2007年 / 32卷 / 8-9期

关键词：

smart polymers; polymer-protein conjugates; site-specific conjugation; affinity precipitation;

D O I：

10.1016/j.progpolymsci.2007.05.005

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

This chapter focuses on the synthesis and applications of covalent conjugates of proteins and stimuli-responsive or "smart" polymers. Smart polymer-drug conjugates are included only when the drug is a protein. The conjugation of biotinylated smart polymers to streptavidin is included, as is the use of streptavidin to link a biotinylated protein and a biotinylated smart polymer. Proteins that are conjugated with poly(ethylene glycol) (PEG), or "PEGylated" proteins, are not included in this chapter since PEG is not utilized as a smart polymer in such conjugates. Smart polymer-protein conjugates immobilized on solid surfaces or within hydrogels are also not included, unless they represent the "phase-separated state" of the reversible soluble-insoluble phases of the conjugate. (C) 2007 Elsevier Ltd. All rights reserved.

引用

页码：922 / 932

页数：11

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