Phosphatidylinositol transfer proteins and functional specification of lipid signaling pools

被引：12

作者：

Bankaitis, Vytas A. ^{[1
]}

Vincent, Patrick ^{[1
]}

Merkulova, Maria ^{[1
]}

Tyeryar, Kim ^{[1
]}

Liu, Yang ^{[1
]}

机构：

[1] Univ N Carolina, Sch Med, Lineberger Comprehens Canc Ctr, Dept Cell & Dev Biol, Chapel Hill, NC 27599 USA

来源：

ADVANCES IN ENZYME REGULATION, VOL 47 | 2007年 / 47卷

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/j.advenzreg.2006.12.007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The diversity of lipid species in biological membranes testifies to the multiple roles of these molecules as structural units, precursors to second messengers, as scaffolding units that impose spatial and temporal regulation on assembly of proteins, and as regulators of the catalytic activities of proteins. Such diverse lipid functions must be appropriately coordinated so that these can be specifically and appropriately coupled to dedicated biological processes. Evidence from multiple sources is building towards a concept where Sec14-like PITPs are specific components of lipid metabolic nanoreactors and, in this capacity, help impose a functional specification of lipid signaling pools. © 2007 Elsevier Ltd. All rights reserved.

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页码：27 / +

页数：4

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