Studies on the generation of unnatural C-nucleosides with 1-alkynyl-2-deoxy-D-riboses

被引：27

作者：

Adamo, Mauro F. A. ^{[1
]}

Pergoli, Roberto ^{[1
]}

机构：

[1] Royal Coll Surgeons Ireland, Ctr Synthesis & Chem Biol, Dept Pharmaceut & Med Chem, Dublin, Ireland

来源：

ORGANIC LETTERS | 2007年 / 9卷 / 22期

关键词：

D O I：

10.1021/ol701794u

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] 1-Alkynyl-2-deoxy-D-riboses 7 and 8 were independently synthesized and subsequently used to generate several novel C-nucleosides.

引用

页码：4443 / 4446

页数：4

共 21 条

[1] A parallel synthesis approach towards a family of C-nucleosides [J].

Adamo, MFA ;

Adlington, RM ;

Baldwin, JE ;

Day, AL .

TETRAHEDRON, 2004, 60 (04) :841-849

[2]

AMENMIYA H, 1993, IMMUNOSUPPRESSIVE DR, P161

[3]

Buchanan J. G., 1982, TOPICS ANTIBIOTIC CH, V6, P229

[4] Sonogashira coupling reaction with diminished homocoupling [J].

Elangovan, A ;

Wang, YH ;

Ho, TI .

ORGANIC LETTERS, 2003, 5 (11) :1841-1844

[5] LOCOREGIONAL IMMUNOSUPPRESSION OF ORGAN TRANSPLANTS [J].

GRUBER, SA .

IMMUNOLOGICAL REVIEWS, 1992, 129 :5-30

[6] Nucleosides and nucleotides.: 175.: Structural requirements of the sugar moiety for the antitumor activities of new nucleoside antimetabolites, 1-(3-C-ethynyl-β-D-ribo-pentofuranosyl)cytosine and -uracil [J].

Hattori, H ;

Nozawa, E ;

Iino, T ;

Yoshimura, Y ;

Shuto, S ;

Shimamoto, Y ;

Nomura, M ;

Fukushima, M ;

Tanaka, M ;

Sasaki, T ;

Matsuda, A .

JOURNAL OF MEDICINAL CHEMISTRY, 1998, 41 (15) :2892-2902

[7] BIOACTIVE MARINE METABOLITES .9. MYCALISINE-A AND MYCALISINE-B, NOVEL NUCLEOSIDES WHICH INHIBIT CELL-DIVISION OF FERTILIZED STARFISH EGGS, FROM THE MARINE SPONGE MYCALE SP [J].

KATO, Y ;

FUSETANI, N ;

MATSUNAGA, S ;

HASHIMOTO, K .

TETRAHEDRON LETTERS, 1985, 26 (29) :3483-3486

[8] The utility of vinyl ethers and vinyl esters in the Khand reaction. The value of vinyl esters as ethylene equivalents and a modified synthesis of (+)-taylorione as an example [J].

Kerr, WJ ;

McLaughlin, M ;

Pauson, PL ;

Robertson, SM .

JOURNAL OF ORGANOMETALLIC CHEMISTRY, 2001, 630 (01) :104-117

[9] SYNTHESIS AND ANTIPROLIFERATIVE AND ANTIVIRAL ACTIVITY OF 2'-DEOXY-2'-FLUOROARABINOFURANOSYL ANALOGS OF THE NUCLEOSIDE ANTIBIOTICS TOYOCAMYCIN AND SANGIVAMYCIN [J].

KRAWCZYK, SH ;

NASSIRI, MR ;

KUCERA, LS ;

KERN, ER ;

PTAK, RG ;

WOTRING, LL ;

DRACH, JC ;

TOWNSEND, LB .

JOURNAL OF MEDICINAL CHEMISTRY, 1995, 38 (20) :4106-4114

[10]

LOU Y, 2006, TETRAHEDRON, V62, P2465

← 1 2 3 →