A parallel synthesis approach towards a family of C-nucleosides

被引：22

作者：

Adamo, MFA

Adlington, RM

Baldwin, JE

Day, AL

机构：

[1] Royal Coll Surgeons Ireland, Ctr Synth & Chem Biol, Dept Pharmaceut & Med Chem, Dublin 2, Ireland

[2] Univ Oxford, Dyson Perrins Lab, Oxford OX1 3QY, England

来源：

TETRAHEDRON | 2004年 / 60卷 / 04期

关键词：

C-nucteosides; parallel synthesis;

D O I：

10.1016/j.tet.2003.11.055

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A synthetic route was devised for a sugar based alpha-chloroketone, which was subsequently used to generate a family of C-nucleosides via parallel synthetic methodology. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：841 / 849

页数：9

共 35 条

[1] A versatile synthetic route to quinoxaline, pyrazine and 1,2,4-triazine substituted α-amino acids from vicinal tricarbonyls [J].

Adlington, RM ;

Baldwin, JE ;

Catterick, D ;

Pritchard, GJ .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 2000, (03) :299-302

[2] The synthesis of novel heterocyclic substituted α-amino acids;: further exploitation of α-amino acid alkynyl ketones as reactive substrates [J].

Adlington, RM ;

Baldwin, JE ;

Catterick, D ;

Pritchard, GJ ;

Tang, LT .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 2000, (15) :2311-2316

[3] The efficient, enantioselective synthesis of quinoxaline, pyrazine and 1,2,4-triazine substituted α-amino acids from vicinal tricarbonyls [J].

Adlington, RM ;

Baldwin, JE ;

Catterick, D ;

Pritchard, GJ .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 2001, (07) :668-679

[4] The synthesis of novel heterocyclic substituted α-amino acids;: further exploitation of α-amino acid alkynyl ketones [J].

Adlington, RM ;

Baldwin, JE ;

Catterick, D ;

Pritchard, GJ ;

Tang, LT .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 2000, (03) :303-305

[5] The synthesis of pyrimidin-4-yl substituted α-amino acids.: A versatile approach from alkynyl ketones [J].

Adlington, RM ;

Baldwin, JE ;

Catterick, D ;

Pritchard, GJ .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1999, (08) :855-866

[6] Synthesis of novel C-nucleosides with potential applications in combinatorial and parallel synthesis [J].

Adlington, RM ;

Baldwin, JE ;

Pritchard, GJ ;

Spencer, KC .

TETRAHEDRON LETTERS, 2000, 41 (04) :575-578

[7]

ADLINGTON RM, 1997, J CHEM SOC CHEM COMM, P1757

[8]

AMENMIYA H, 1993, IMMUNOSUPPRESSIVE DR, P161

[9] Novel C-4 heteroaromatic kainoid analogues: A parallel synthesis approach [J].

Baldwin, JE ;

Fryer, AM ;

Pritchard, GJ .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2000, 10 (03) :309-311

[10] The synthesis of 4-arylsulfanyl-substituted kainoid analogues from trans-4-hydroxy-L-proline [J].

Baldwin, JE ;

Pritchard, GJ ;

Williamson, DS .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2000, 10 (17) :1927-1929

← 1 2 3 4 →