Estrogen-related receptor expression in placenta throughout gestation

被引：33

作者：

Fujimoto, J ^{[1
]}

Nakagawa, Y ^{[1
]}

Toyoki, H ^{[1
]}

Sakaguchi, H ^{[1
]}

Sato, E ^{[1
]}

Tamaya, T ^{[1
]}

机构：

[1] Gifu Univ, Sch Med, Dept Obstet & Gynecol, Gifu 5011194, Japan

来源：

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY | 2005年 / 94卷 / 1-3期

关键词：

estrogen-related receptor; estrogen receptor; endometrial cancer;

D O I：

10.1016/j.jsbmb.2004.12.030

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Estrogen receptor (ER) alpha and beta mRNA levels increased from the first to the second trimester and then decreased until normal term delivery. Estrogen-related receptor (ERR) alpha, beta and gamma mRNA levels gradually increased up to the second trimester and then comparatively rapidly increased until normal term delivery. ERRs can bind to the steroid receptor coactivator family without any ligands and drive transcription activity of the target genes. The manner of ERR and ER gene expressions might show a competitive interaction associated with the use of common cofactors. It is speculated that the up-regulation of ERRs is related to placental growth after the down-regulation of ERs because of the remarkably high concentration of estrogens for ERs from the second trimester until delivery. (c) 2004 Elsevier Ltd. All rights reserved.

引用

页码：67 / 69

页数：3

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