Treatment of meningitis due to methicillin-resistant Staphylococcus epidermidis with linezolid

被引：35

作者：

Krueger, WA

Kottler, B

Will, BE

Heininger, A

Guggenberger, H

Unertl, KE

机构：

[1] Univ Tubingen Hosp, Dept Anesthesiol & Intens Care Med, D-72076 Tubingen, Germany

[2] Univ Tubingen Hosp, Dept Neurosurg, D-72076 Tubingen, Germany

来源：

JOURNAL OF CLINICAL MICROBIOLOGY | 2004年 / 42卷 / 02期

关键词：

D O I：

10.1128/JCM.42.2.929-932.2004

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Methicillin-resistant Staphylococcus epidermidis (MRSE) can cause nosocomial meningitis in the presence of prosthetic devices. Vancomycin is the treatment of choice, but its penetration into the cerebrospinal fluid is poor, especially in cases without severe meningeal inflammation. We successfully used linezolid to treat a case of posttraumatic MRSE meningitis with a low-level inflammatory response. Therapeutic effectiveness was documented microbiologically and by the simultaneous measurement of linezolid levels in serum and cerebrospinal fluid.

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页码：929 / +

页数：5

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