Peptide ligation by a reversible and reusable C-terminal thiol handle

被引：16

作者：

Lu, YA

Tam, JP ^{[1
]}

机构：

[1] Scripps Res Inst, Dept Biomed Res, Jupiter, FL 33458 USA

[2] Nanyang Technol Univ, Sch Biol Sci, Singapore 637551, Singapore

来源：

ORGANIC LETTERS | 2005年 / 7卷 / 22期

关键词：

D O I：

10.1021/ol052000f

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] Peptide ligation of noncysteinyl residues can be achieved conveniently by a reversible C-terminal thiol handle together with a Ag+ ion-assisted S,N-acyl migration. The regenerated C-terminal handle permits tandem ligation of multiple segment.

引用

收藏

页码：5003 / 5006

页数：4

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