Functional mapping of somatostatin receptors in the retina: a review

被引：67

作者：

Thermos, K ^{[1
]}

机构：

[1] Univ Crete, Fac Med, Dept Basic Sci, Pharmacol Lab, Iraklion 71110, Crete, Greece

来源：

VISION RESEARCH | 2003年 / 43卷 / 17期

关键词：

neural retina; retinal pigment epithelium; somatostatin receptors; NADPH-diaphorase; tyrosine hydroxylase; PROLIFERATIVE DIABETIC-RETINOPATHY; CENTRAL-NERVOUS-SYSTEM; NITRIC-OXIDE SYNTHASE; SUBTYPE 2A EXPRESSION; ADULT CAT RETINA; IGF-I LEVELS; RABBIT RETINA; RAT RETINA; MOLECULAR-CLONING; NADPH-DIAPHORASE;

D O I：

10.1016/S0042-6989(03)00169-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The peptide somatostatin is one of many neuroactive agents that influence retinal physiology. It is synthesized primarily in a subclass of amacrine cells and believed to function as a neurotransmitter, neuromodulator or trophic factor. The cloning of the somatostatin receptors (SSt(1-5)) in the early nineties provided the appropriate tools for the study of sst(s) in many tissues, including the retina. In this review, emphasis is given to recent studies that have provided significant information on the functional role of somatostatin in retinal circuitry and the retinal pigment epithelium. The important role of somatostatin in retinal disease therapeutics is also discussed. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：1805 / 1815

页数：11

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