A stereoselective synthesis of a 2-functionalized-methyl-1β-methylcarbapenem key intermediate via decarboxylation

被引:8
作者
Choi, WB [1 ]
Lee, J [1 ]
Lynch, JE [1 ]
Volante, RP [1 ]
Reider, PJ [1 ]
Reamer, RA [1 ]
机构
[1] Merck Res Labs, Rahway, NJ 07065 USA
关键词
D O I
10.1039/a804125c
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
An efficient synthesis of a key intermediate 2a for the synthesis of 2-functionalized methyl-1 beta-methylcarbapenem antibiotics 1 has been realized via a stereoselective decarboxylation reaction.
引用
收藏
页码:1817 / 1818
页数:2
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