Anti-hyperactivity medication: methylphenidate and amphetamine

被引：190

作者：

Seeman, P

Madras, BK

机构：

[1] Univ Toronto, Dept Pharmacol, Toronto, ON M5S 1A8, Canada

[2] Univ Toronto, Dept Psychiat, Toronto, ON M5S 1A8, Canada

[3] Harvard Univ, New England Reg Primate Res Ctr, Sch Med, Dept Psychiat,Div Neurochem, Southborough, MA 01772 USA

来源：

MOLECULAR PSYCHIATRY | 1998年 / 3卷 / 05期

关键词：

hyperactivity; attention deficit; methylphenidate; amphetamine; dopamine;

D O I：

10.1038/sj.mp.4000421

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

How do 'stimulants' reduce hyperactivity in children and adults? How can drugs which raise extracellular dopamine result in psychomotor slowing of hyperactive children when dopamine is known to enhance motor activity, such as in Parkinson's disease? These apparent paradoxes are the focus of this brief review on the mechanism of action of stimulant medications used in the treatment of children, and of an increasing number of adults who meet diagnostic criteria for attention deficit hyperactivity disorder.

引用

页码：386 / 396

页数：11

共 105 条

[31] NONLINEAR RELATIONSHIP BETWEEN IMPULSE FLOW AND DOPAMINE RELEASED BY RAT MIDBRAIN DOPAMINERGIC-NEURONS AS STUDIED BY INVIVO ELECTROCHEMISTRY [J].