Activity-based probes: discovering new biology and new drug targets

被引：159

作者：

Heal, William P. ^{[1
]}

Dang, T. H. Tam ^{[1
]}

Tate, Edward W. ^{[1
,2
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Dept Chem, London SW7 2AZ, England

[2] Univ London Imperial Coll Sci Technol & Med, Inst Biol Chem, London SW7 2AZ, England

来源：

CHEMICAL SOCIETY REVIEWS | 2011年 / 40卷 / 01期

基金：

英国医学研究理事会; 英国生物技术与生命科学研究理事会;

关键词：

BIOORTHOGONAL LIGATION CHEMISTRY; CHEMICAL-PROTEOMIC TOOLS; N-MYRISTOYL TRANSFERASE; FATTY-ACID SYNTHASE; IN-VIVO; CLOSTRIDIUM-DIFFICILE; SERINE HYDROLASES; CLICK CHEMISTRY; PROTEIN; ENZYME;

D O I：

10.1039/c0cs00004c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The development and application of chemical technologies enabling direct analysis of enzyme activity in living systems has undergone explosive growth in recent years. Activity-based protein profiling (ABPP) is a key constituent of this broad field, and is among the most powerful and mature chemical proteomic technologies. This tutorial review introduces the essential features of ABPP and the design and application of activity-based probes (ABPs) from drug target elucidation and in vivo visualisation of enzyme activity to comprehensive profiling of the catalytic content of living systems, and the discovery of new biological pathways.

引用

页码：246 / 257

页数：12

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