Controlled Delivery Using Oligonucleotide-Capped Mesoporous Silica Nanoparticles

被引：211

作者：

Climent, Estela ^{[1
,2
]}

Martinez-Manez, Ramon ^{[1
,2
]}

Sancenon, Felix ^{[1
,2
]}

Marcos, Maria D. ^{[1
,2
]}

Soto, Juan ^{[1
,2
]}

Maquieira, Angel ^{[1
,2
]}

Amoros, Pedro ^{[3
]}

机构：

[1] Univ Valencia, Unidad Mixta Univ Politecn Valencia, Ctr Reconocimiento Mol & Desarrollo Tecnol IDM, E-46003 Valencia, Spain

[2] Univ Politecn Valencia, Dept Quim, Valencia 46022, Spain

[3] Univ Valencia, Inst Ciencia Dels Mat ICMUV, E-46003 Valencia, Spain

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2010年 / 49卷 / 40期

关键词：

host-guest systems; mesoporous materials; molecular gates; nanoparticles; oligonucleotides; RESPONSIVE CONTROLLED-RELEASE; DRUG-DELIVERY; SCAFFOLDINGS; ENSEMBLES; SYSTEM; DRIVEN; DNA;

D O I：

10.1002/anie.201001847

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Caps off! A single-stranded oligonucleotide capped the pores on the surface of a silica mesoporous support, which contained an entrapped guest. In the presence of a complementary strand, the "molecular lock" on the delivery vehicle was opened and the entrapped guests were selectively released. (Figure presented). © 2010 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

收藏

页码：7281 / 7283

页数：3

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