Effects of chronic and acute ozone exposure on lipid peroxidation and antioxidant capacity in healthy young adults

被引:80
作者
Chen, Connie
Arjomandi, Mehrdad
Balmes, John
Tager, Ira
Holland, Nina
机构
[1] Univ Calif Berkeley, Sch Publ Hlth, Div Environm Hlth Sci, Berkeley, CA 94720 USA
[2] Univ Calif San Francisco, Dept Med, Lung Biol Ctr, San Francisco, CA USA
[3] Univ Calif Berkeley, Sch Publ Hlth, Div Epidemiol, Berkeley, CA 94720 USA
关键词
antioxidant capacity; FRAP; isoprostane; lifetime exposure; lipid peroxidation; plasma; oxidative injury; ozone;
D O I
10.1289/ehp.10294
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
BACKGROUND: There is growing evidence for the role of oxidative damage in chronic diseases. Although ozone (O-3) is an oxidant pollutant to which many people are exposed, few studies have examined whether O-3 induces oxidative stress in humans. OBJECTIVES: This study was designed to assess the effect of short, and Ion term O-3 exposures on biomarkers of oxidative stress in healthy individuals. METHODS: Biomarkers of lipid peroxidation, 8-isoprostane (8-iso-PGF), and antioxidant capacity ferric reducing ability of plasma (FRAP) were analyzed in two groups of healthy college students with broad ranges of ambient O-3 exposure during their lifetimes and previous summer recess either in Los Angeles (LA, n = 59) or the San Francisco Bay Area (SF, n = 61). RESULTS: Estimated 2-week, 1-month, and lifetime O-3 exposures were significantly correlated with elevated 8-iso-PGF. Elevated summertime exposures resulted in the LA group having higher levels of 8-iso-PGF than the SF group (p = 0.02). Within each location, males and females had similar 8-iso-PGF. No regional difference in FRAP was observed, with significantly higher FRAP in males in both groups (SF: p = 0.002; LA: p = 0.004). An exposure chamber substudy (n = 15) also showed a significant increase in 8-iso-PGF as well as an inhibition of FRAP immediately after a 4-hr exposure to 200 ppb O-3, with near normalization by 18 hr in both biomarkers. CONCLUSIONS: Long-term exposure to O-3 is associated with elevated 8-iso-PGF, which suggests that 8-iso-PGF is a good biomarker of oxidative damage related to air pollution.
引用
收藏
页码:1732 / 1737
页数:6
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