Binding of D-serine-terminating cell-wall analogues to glycopeptide antibiotics

被引：16

作者：

van Wageningen, AMA ^{[1
]}

Staroske, T ^{[1
]}

Williams, DH ^{[1
]}

机构：

[1] Univ Cambridge, Cambridge Ctr Mol Recognit, Chem Lab, Cambridge CB2 1EW, England

来源：

CHEMICAL COMMUNICATIONS | 1998年 / 11期

关键词：

D O I：

10.1039/a801030g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Binding studies of -L-Lys-D-Ala-D-Ser-terminating ligands, used as model systems for cell-wall precursors found in VanC resistant bacteria, with vancomycin, chloroeremomycin and teicoplanin show that they bind to these glycopeptides in a similar manner as -L-Lys-D-Ala-D-Ala-terminating ligands, but that the binding constants are one to two orders of magnitude lower.

引用

页码：1171 / 1172

页数：2

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