Facile access to polysubstituted Indoles via a cascade Cu-catalyzed arylation - Condensation process

被引：117

作者：

Chen, Yu

Xie, Xiaoan

Ma, Dawei

机构：

[1] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Bioorganic & Nat Prod Chem, Shanghai 200323, Peoples R China

[2] Fudan Univ, Dept Chem, Shanghai 200433, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2007年 / 72卷 / 24期

关键词：

D O I：

10.1021/jo702059q

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[Graphics] CuI/L-proline-catalyzed cross-coupling of 2-halotrifluoroacetanilides with beta-keto esters and amides followed by in situ acidic hydrolysis delivered 2,3-disubstituted indoles. The halides bearing a strong electron-withdrawing group in the 4-position can undergo in situ basic hydrolysis to provide the corresponding indoles. Polysubstituted indoles can be prepared from substituted 2-halotrifluoroacetanilides with high regioselectivity.

引用

页码：9329 / 9334

页数：6

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