In situ-gelling, erodible N-isopropylacrylamide copolymers

被引：35

作者：

Lee, BH ^{[1
]}

Vernon, B ^{[1
]}

机构：

[1] Arizona State Univ, Harrington Dept Bioengn, Tempe, AZ 85287 USA

来源：

MACROMOLECULAR BIOSCIENCE | 2005年 / 5卷 / 07期

关键词：

bioerodible; gelation; injectable; PNIPAAm; stimuli-sensitive polymers;

D O I：

10.1002/mabi.200500029

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Copolymers of N-isopropylacrylamide, 2-hydroxyethyl methacryl lactate [(HEMA)-lactate] and acrylic acid (AAc) were prepared with varying mole ratios of monomers to develop copolymers with gelation properties above a certain concentration for a bioerodible, in-situ gelling material. The copolymers formed gels in situ under physiological condition. The gelation temperature of the copolymers decreased as the HEMA-lactate content of the copolymers increased due to the hydrophobicity of HEMA-lactate, and increased as the AAc content increased due to the hydrophilicity of AAc. The gels redissolve at 37 degrees C as their LCSTs increase above 37 degrees C due to the hydrolysis of the HEMA-lactate pendant groups.

引用

页码：629 / 635

页数：7

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