Therapeutic applications of compounds in the Magnolia family

被引：428

作者：

Lee, Young-Jung ^{[1
,2
]}

Lee, Yoot Mo ^{[1
,2
,3
]}

Lee, Chong-Kil ^{[1
,2
]}

Jung, Jae Kyung ^{[1
,2
]}

Han, Sang Bae ^{[1
,2
]}

Hong, Jin Tae ^{[1
,2
]}

机构：

[1] Chungbuk Natl Univ, Coll Pharm, Cheongju 361763, Chungbuk, South Korea

[2] Chungbuk Natl Univ, Med Res Ctr, Cheongju 361763, Chungbuk, South Korea

[3] Korea Food & Drug Adm, Bioequivalence Evaluat Div, Drug Evaluat Dept Pharmaceut Safety Breau, Seoul, South Korea

来源：

PHARMACOLOGY & THERAPEUTICS | 2011年 / 130卷 / 02期

关键词：

Magnolia; Magnolol; Obovatol; Honokiol; 4-O-methylhonokiol; Cancer; Nerve; Alzheimer disease; Cardiovascular disease; Inflammatory disease; NF-KAPPA-B; FOCAL CEREBRAL-ISCHEMIA; I FLOS-MAGNOLIAE; PLATELET-ACTIVATING-FACTOR; GINKGO-BILOBA EXTRACT; SMOOTH-MUSCLE-CELLS; BANXIA-HOUPO-TANG; ANTIDEPRESSANT-LIKE SYNERGISM; HONOKIOL INDUCES APOPTOSIS; NITRIC-OXIDE PRODUCTION;

D O I：

10.1016/j.pharmthera.2011.01.010

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The bark and/or seed cones of the Magnolia tree have been used in traditional herbal medicines in Korea, China and Japan. Bioactive ingredients such as magnolol, honokiol, 4-O-methylhonokiol and obovatol have received great attention, judging by the large number of investigators who have studied their pharmacological effects for the treatment of various diseases. Recently, many investigators reported the anti-cancer, anti-stress, anti-anxiety, anti-depressant, anti-oxidant, anti-inflammatory and hepatoprotective effects as well as toxicities and pharmacokinetics data, however, the mechanisms underlying these pharmacological activities are not clear. The aim of this study was to review a variety of experimental and clinical reports and, describe the effectiveness, toxicities and pharmacokinetics, and possible mechanisms of Magnolia and/or its constituents. (C) 2011 Elsevier Inc. All rights reserved.

引用

页码：157 / 176

页数：20

共 272 条

[1] Curcumin (diferuloylmethane) down-regulates expression of cell proliferation and antiapoptotic and metastatic gene products through suppression of IκBα kinase and Akt activation [J].