Synthesis, cytotoxicity, and antiviral activities of new neolignans related to honokiol and magnolol

被引：67

作者：

Amblard, Franck

Govindarajan, Baskaran

Lefkove, Benjamin

Rapp, Kimberly L.

Detorio, Mervi

Arbiser, Jack L.

Schinazi, Raymond F. ^{[1
]}

机构：

[1] Vet Affairs Med Ctr, Atlanta, GA 30333 USA

[2] Emory Univ, Dept Pediat & Dermatol, Atlanta, GA 30322 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2007年 / 17卷 / 16期

关键词：

antiviral; anti-tumoral; honokiol; magnolol; neolignans; RIE-1; EPITHELIAL-CELLS; NATURAL-PRODUCT; IN-VIVO; OFFICINALIS; GROWTH; AGENTS; ANGIOSARCOMA; APOPTOSIS; MICE;

D O I：

10.1016/j.bmcl.2007.06.024

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of new bisphenol derivatives bearing allylic moieties were synthesized as potential analogs of honokiol and/or magnolol. Certain compounds exhibited specific anti-proliferation activity against SVR cells and moderate anti-HIV-1 activity in primary human lymphocytes. Compound 5h was the most potent compound and its anti-tumor activity was evaluated in vivo. Published by Elsevier Ltd.

引用

收藏

页码：4428 / 4431

页数：4

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