Large-Scale Analysis Reveals Acquisition of Lineage-Specific Chromosomal Aberrations in Human Adult Stem Cells

被引：188

作者：

Ben-David, Uri ^{[1
]}

Mayshar, Yoav ^{[1
]}

Benvenisty, Nissim ^{[1
]}

机构：

[1] Hebrew Univ Jerusalem, Stem Cell Unit, Dept Genet, Silberman Inst Life Sci, IL-91904 Jerusalem, Israel

来源：

CELL STEM CELL | 2011年 / 9卷 / 02期

关键词：

CULTURE ADAPTATION; COPY NUMBER; IN-VITRO; PLURIPOTENCY; CLASSIFICATION; TRANSFORMATION; ABNORMALITIES; INSTABILITY; MALIGNANCY; MUTATIONS;

D O I：

10.1016/j.stem.2011.06.013

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

In this study, we assessed the genetic integrity of over 400 samples of human multipotent stem cells using gene expression data sets. Our analysis reveals that neural and mesenchymal stem cells acquire characteristic large chromosomal aberrations at a similar, or somewhat lower, frequency to that seen in pluripotent stem cells, sometimes within a few passages in culture. Some of the identified chromosomal abnormalities can also be detected in human tumors of the respective tissues.

引用

页码：97 / 102

页数：6

共 30 条

[1] Donor-Derived Brain Tumor Following Neural Stem Cell Transplantation in an Ataxia Telangiectasia Patient [J].

Amariglio, Ninette ;

Hirshberg, Abraham ;

Scheithauer, Bernd W. ;

Cohen, Yoram ;

Loewenthal, Ron ;

Trakhtenbrot, Luba ;

Paz, Nurit ;

Koren-Michowitz, Maya ;

Waldman, Dalia ;

Leider-Trejo, Leonor ;

Toren, Amos ;

Constantini, Shlomi ;

Rechavi, Gideon .

PLOS MEDICINE, 2009, 6 (02) :221-231

[2] Adaptation to culture of human embryonic stem cells and oncogenesis in vivo [J].

Baker, Duncan E. C. ;

Harrison, Neil J. ;

Maltby, Edna ;

Smith, Kath ;

Moore, Harry D. ;

Shaw, Pamela J. ;

Heath, Paul R. ;

Holden, Hazel ;

Andrews, Peter W. .

NATURE BIOTECHNOLOGY, 2007, 25 (02) :207-215

[3] The tumorigenicity of human embryonic and induced pluripotent stem cells [J].

Ben-David, Uri ;

Benvenisty, Nissim .

NATURE REVIEWS CANCER, 2011, 11 (04) :268-277

[4] Genetic instability in human induced pluripotent stem cells Classification of causes and possible safeguards [J].

Ben-David, Uri ;

Benvenisty, Nissim ;

Mayshar, Yoav .

CELL CYCLE, 2010, 9 (23) :4603-4604

[5] Human bone marrow-derived mesenchymal stem cells do not undergo transformation after long-term In vitro culture and do not exhibit telomere maintenance mechanisms [J].

Bernardo, Maria Ester ;

Zaffaroni, Nadia ;

Novara, Francesca ;

Cometa, Angela Maria ;

Avanzini, Maria Antonietta ;

Moretta, Antonia ;

Montagna, Daniela ;

Maccario, Rita ;

Villa, Raffaella ;

Daidone, Maria Grazia ;

Zuffardi, Orsetta ;

Locatelli, Franco .

CANCER RESEARCH, 2007, 67 (19) :9142-9149

[6] Spontaneous Aneuploidy and Clone Formation in Adipose Tissue Stem Cells during Different Periods of Culturing [J].

Buyanovskaya, O. A. ;

Kuleshov, N. P. ;

Nikitina, V. A. ;

Voronina, E. S. ;

Katosova, L. D. ;

Bochkov, N. P. .

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2009, 148 (01) :109-112

[7] Tumorigenic Potential of Olfactory Bulb-Derived Human Adult Neural Stem Cells Associates with Activation of TERT and NOTCH1 [J].

Casalbore, Patrizia ;

Budoni, Manuela ;

Ricci-Vitiani, Lucia ;

Cenciarelli, Carlo ;

Petrucci, Giovanna ;

Milazzo, Luisa ;

Montano, Nicola ;

Tabolacci, Elisabetta ;

Maira, Giulio ;

Larocca, Luigi M. ;

Pallini, Roberto .

PLOS ONE, 2009, 4 (02)

[8] Clustering of deletions on chromosome 13 in benign and low-malignant lipomatous tumors [J].

Dahlén, A ;

Debiec-Rychter, M ;

Pedeutour, F ;

Domanski, HA ;

Höglund, M ;

Bauer, HCF ;

Rydholm, A ;

Sciot, R ;

Mandahl, N ;

Mertens, F .

INTERNATIONAL JOURNAL OF CANCER, 2003, 103 (05) :616-623

[9] A novel, immortal, and multipotent human neural stem cell line generating functional neurons and Oligodendrocytes [J].

De Filippis, Lidia ;

Lamorte, Giuseppe ;

Snyder, Evan Y. ;

Malgaroli, Antonio ;

Vescovi, Angelo L. .

STEM CELLS, 2007, 25 (09) :2312-2321

[10] Somatic coding mutations in human induced pluripotent stem cells [J].

Gore, Athurva ;

Li, Zhe ;

Fung, Ho-Lim ;

Young, Jessica E. ;

Agarwal, Suneet ;

Antosiewicz-Bourget, Jessica ;

Canto, Isabel ;

Giorgetti, Alessandra ;

Israel, Mason A. ;

Kiskinis, Evangelos ;

Lee, Je-Hyuk ;

Loh, Yuin-Han ;

Manos, Philip D. ;

Montserrat, Nuria ;

Panopoulos, Athanasia D. ;

Ruiz, Sergio ;

Wilbert, Melissa L. ;

Yu, Junying ;

Kirkness, Ewen F. ;

Izpisua Belmonte, Juan Carlos ;

Rossi, Derrick J. ;

Thomson, James A. ;

Eggan, Kevin ;

Daley, George Q. ;

Goldstein, Lawrence S. B. ;

Zhang, Kun .

NATURE, 2011, 471 (7336) :63-U76

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