CASP9 results compared to those of previous CASP experiments

被引：50

作者：

Kryshtafovych, Andriy ^{[2
]}

Fidelis, Krzysztof ^{[2
]}

Moult, John ^{[1
,3
]}

机构：

[1] Univ Maryland, Inst Biosci & Biotechnol Res, Rockville, MD 20850 USA

[2] Univ Calif Davis, Genome Ctr, Davis, CA 95616 USA

[3] Univ Maryland, Dept Cell Biol & Mol Genet, Rockville, MD 20850 USA

来源：

PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS | 2011年 / 79卷

关键词：

protein structure prediction; community wide experiment; CASP; PROGRESS;

D O I：

10.1002/prot.23182

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The quality of structure models submitted to CASP9 is analyzed in the context of previous CASPs. Comparison methods are similar to those used in previous articles in this series, with the addition of new methods looking at model quality in regions not covered by a single best structural template, alignment accuracy, and progress for template-free models. Progress in this CASP was again modest and statistically hard to validate. Nevertheless, there are several positive trends. There is an indication of improvement in overall model quality for the midrange of template-based modeling difficulty, methods for identifying the best model from a set generated have improved, and there are strong indications of progress in the quality of template-free models of short proteins. In addition, the new examination of a model quality in regions of model not covered by the best available template reveals better performance than had previously been apparent. Proteins 2011; 79(Suppl 10): 196-207. (C) 2011 Wiley-Liss, Inc.

引用

页码：196 / 207

页数：12

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